Getting to know the potential side effects of using CBD oil

CBD oil has numerous benefits, but some consumers have reported potential side effects. Learn more about the potential side effects of CBD oil below, including dry mouth, liver damage, dizziness, and digestive issues.

Cannabidiol (CBD) has dominated the market with its amazing health benefits. Numerous industries have been established to cater to CBD products' high demand. As a result, CBD brands manufacture a wide product range to satisfy different customers. They come in various formulations, including CBD capsules, gummies, vapes, topicals, and oils. CBD oil is the most preferred consumption method because the CBD effects remain for a long period. Although CBD oil has numerous benefits, some potential side effects are reported. Some include irritability, liver damage potential, dry mouth, drowsiness, dizziness, and digestive issues. Therefore, CBD consumers should be vigilant when using CBD oil to evade adverse side effects.


What is CBD Oil

Cannabidiol (CBD) is a chemical cannabinoid compound in cannabis and hemp plants. It constitutes the main cannabis components that function throughout the human body. This compound is escalating notably because of its massive therapeutic benefits. Moreover, it does not have psychoactive and euphoric effects whenever consumed. Contrastingly, tetrahydrocannabinol (THC), an active cannabis molecule, causes high effects by interfering with human brain operation. Unlike CBD, THC has intoxicating effects. Cannabidiol (CBD) comes in a range of formulations. For example, CBD oil is produced from cannabis herb and diluted with coconut or olive oil (carrier oils). This process boosts bioavailability, meaning that the body absorbs it better.


Common Side Effects of Cannabidiol Oil

CBD’s side effects include irritability, liver damage potential, dry mouth, drowsiness, dizziness, and digestive issues.


Drowsiness and Fatigue

The utilization of cannabidiol oil might cause sedation and drowsiness. According to Vázquez et al. (2020), these effects might intensify when consuming CBD with other drugs. CBD consumers report tiredness and sleepiness after taking cannabidiol oil. If the symptoms are extreme, you are prohibited from operating or driving heavy machinery. The cannabidiol effect is biphasic, meaning that high amounts might elevate sleeping time while low doses enhance wakefulness. The human endocannabinoid receptors levels are determined by circadian rhythm. This might outline why cannabidiol induces drowsiness in later hours but display the opposite effect during the morning.


Digestive Issues

Both Food and Drug Administration (FDA) - certified cannabidiol Epidiolex drugs and cannabidiol oil supplements cause certain digestive disorders. They include diarrhea, reduced or increased appetite, weight gain or loss, vomiting, and nausea. Hatem et al. (2018) proposed that other ingredients in CBD oil, like carrier oils, contribute to these effects. Alternatively, the weak supplement regulation might allow excessive cannabidiol contents in extracts or hazardous contaminants, including solvents, heavy metals, and pesticides. In response, the body's endocannabinoid system plays an essential function in improving appetite. The CBD's combined effects on weight and appetite might result from a dual effect. It impedes CB2 and CB1 receptors but improves the amounts of their stimulator anandamide. If you experience digestive disorders after consuming cannabidiol, consult with your medical provider. They might prescribe lowering the amount or adjusting to another trademark.


Dry Mouth

Whether used for medicinal or recreational roles, cannabis products cause a consumer’s mouth to feel like they are satiated with cotton pellets. Salim et al. (2005) established that out of 1500 CBD consumers, 15 percent experience dry mouth. For this reason, this side effect is common in CBD enthusiasts. Stimulating CB2 and CB1 receptors in the salivary glands lower saliva secretion, making the mouth dry. The popular THC cannabis compound stimulates these receptors unswervingly. Consequently, cannabidiol elevates the amounts of activator generated naturally by the body called cannabinoid anandamide.


Dizziness

Jadoon et al. (2017) suggested that high CBD doses reduce blood pressure in people. However, THC contains a more complicated impact. For instance, it partially hikes blood pressure in individuals sitting down but elevates the prompt blood pressure drop risks when rising. Consequently, a prevalent negative CBD effect occurs solely with equivalent THC (nabiximols) amounts. This induces light-headedness and dizziness in CBD consumers. If the blood pressure reduces to the extreme, an individual might faint. Individuals using blood pressure drugs like beta-blockers, ACE inhibitors, and diuretics have high chances of fainting. Therefore, they should be vigilant with cannabidiol oil and avoid taking it without the doctor’s consent.


Potential Liver Damage

According to Shahbaz et al. (2018), cannabidiol can cause potential liver harm in many people. In this regard, the risk elevated with the amount and was greatest in individuals also consuming anti-seizure medication valproate, which causes liver damage. Similarly, cannabidiol has symptoms of liver harmfulness (high alkaline transaminases, bilirubin, and transaminases). However, doses that cause these symptoms are high. Communicate with your doctor if you are consuming valproate and avoid surpassing the prescribed cannabidiol oil amount to lower the chances of destroying the liver.


Irritability

Moderate CBD amounts might effectively address various stressful situations and anxiety disorders. Contrastingly, extremely high doses might stimulate irritability and anxiety. The effect possibly includes the TRPV1 receptor, the activation which makes the brain respond to stressful situations. Cannabidiol improves the naturally-generated cannabinoid anandamide. Although moderate anandamide amounts stimulate CB1 receptors and lower anxiety, high doses might worsen by attaching to TRPV1. Also, CBD stimulates this receptor directly, leading to anxiety-activating effects.


Conclusion

Cannabidiol (CBD) oil is packed with numerous health benefits. Its popularity penetrates every territory, gaining more customers. Most people have shifted to plant-based products, positively affecting different body conditions. However, CBD oil has several side effects, including irritability, liver damage potential, dry mouth, drowsiness, dizziness, and digestive issues. Therefore, speak to your medical provider about CBD usage. Some people claim that CBD oil is safe, and some have ideal tolerance. Nonetheless, low-quality merchandise might have toxins and additives that irritate the gut when consumed orally and the lungs when vaped. Therefore, select premium products to lower side effects risks and reap optimum CBD benefits.


References

Hatem, S., Nasr, M., Moftah, N. H., Ragai, M. H., Geneidi, A. S., & Elkheshen, S. A. (2018). Clinical Cosmeceutical Repurposing Of Melatonin In Androgenic Alopecia Using Nanostructured Lipid Carriers Prepared With Antioxidant Oils. Expert Opinion On Drug Delivery, 15(10), 927-935.

Jadoon, K. A., Tan, G. D., & O’Sullivan, S. E. (2017). A Single Dose Of Cannabidiol Reduces Blood Pressure In Healthy Volunteers In A Randomized Crossover Study. JCI Insight, 2(12).

Salim, K., Schneider, U., Burstein, S., Hoy, L., & Karst, M. (2005). Pain Measurements And Side Effect Profile Of The Novel Cannabinoid Ajulemic Acid. Neuropharmacology, 48(8), 1164-1171. Shahbaz, A., Gaviria, R. E.

E., Shahid, M. F., Yasin, M. A., Ashraf, A., & Zaman, M. A. (2018). Acute Liver Injury Induced By Synthetic Cannabinoid Abuse. Cureus, 10(9).

Vázquez, M., Guevara, N., Maldonado, C., Guido, P. C., & Schaiquevich, P. (2020). Potential Pharmacokinetic Drug-Drug Interactions Between Cannabinoids And Drugs Used For Chronic Pain. BiomedResearch International, 2020.

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